5-Hydroxy Vioxx

• CAT Number: R013109
• CAS Number: 185147-17-5
• Molecular Formula: C17H14O5S
• Molecular Weight: 330.354
• Purity: ≥95%
• Synonyms: 5-Hydroxy-4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone; 5-Hydroxyrofecoxib
• Storage: Store at RT
• IUPAC Name: 2-hydroxy-3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
• InChI: InChI=1S/C17H14O5S/c1-23(20,21)13-9-7-12(8-10-13)15-14(16(18)22-17(15)19)11-5-3-2-4-6-11/h2-10,17,19H,1H3
• InChIKey: NCBVUSNBLYMFPP-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2O)C3=CC=CC=C3

5-Hydroxy Vioxx (CAS 185147-17-5) is a metabolite of Vioxx. The biotransformation of Rofecoxib (Vioxx) is highly dependent on the subcellular fraction and the redox system used.

Reference

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2.John, B. A., et al. "Metabolism of the anti-psoriatic agent 5-methoxypsoralen in humans: comparison with rat and dog." Xenobiotica 22.11 (1992): 1339-1351.
3.Jouzeau, Jean-Yves, et al. "Cyclo-oxygenase isoenzymes." Drugs 53.4 (1997): 563-582.
4.Baillie, Thomas A., et al. "Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques." Drug metabolism and disposition 29.12 (2001): 1614-1628.