For research use only. Not for therapeutic Use.
5-Hydroxydecanoate sodium (CAT: I011405) is a compound that acts as an inhibitor of mitochondrial ATP-sensitive potassium channels (mitoKATP channels). It blocks the opening of these channels, leading to the inhibition of the flow of potassium ions across the mitochondrial inner membrane. This inhibition can have various effects on cellular functions and processes, including mitochondrial metabolism, calcium homeostasis, and cell survival. 5-Hydroxydecanoate sodium has been studied for its potential therapeutic applications in conditions such as myocardial ischemia, neurodegenerative diseases, and metabolic disorders.
| Catalog Number | I011405 |
| CAS Number | 71186-53-3 |
| Molecular Formula | C₁₀H₁₉NaO₃ |
| Purity | ≥95% |
| Target | Potassium Channel |
| Reference | [1]. Congna Zi, et al. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362.<br>[2]. Xiantao Li, et al. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800(3):385-91.<br>[3]. M G Marina Prendes, et al. Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. J Physiol Biochem. 2005 Sep;61(3):447-56. |
