5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

• CAT Number: A000809
• CAS Number: 207679-81-0
• Molecular Formula: C22H31NO2
• Molecular Weight: 341.49
• Purity: ≥95%
• Synonyms: Desfesoterodine
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20 ℃
• InChI: InChI=1S/C22H31NO2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3/t20-/m1/s1
• InChIKey: ZUAQDESYZRTAMM-GKZFYUMFSA-N
• SMILES: C1[C@@H]([C@H](OC2=C1C(=C(C(=C2)O)[C@H]3[C@@H]([C@H](OC4=C3C=CC(=C4)O)C5=CC(=C(C=C5)O)O)O)O)C6=CC(=C(C(=C6)O)O)O)O

5-Hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) is an active metabolite of Tolterodine, a drug primarily used to treat overactive bladder and urinary incontinence. As the major metabolite, 5-HMT contributes significantly to the therapeutic effects of Tolterodine by acting as a potent muscarinic receptor antagonist. Its selective inhibition of muscarinic receptors in the bladder helps reduce involuntary contractions, improving bladder control. 5-Hydroxymethyl Tolterodine plays a critical role in pharmacokinetic studies, drug metabolism research, and the development of treatments for urinary disorders, offering enhanced efficacy with a favorable safety profile.