5-(Hydroxymethyl)cytidine

• CAT Number: R020937
• CAS Number: 19235-17-7
• Molecular Formula: C10H15N3O6
• Molecular Weight: 273.24
• Purity: ≥95%
• Synonyms: 4-amino-1-[(2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(hydroxymethyl)pyrimidin-2-one
• InChI: InChI=1S/C10H15N3O6/c11-8-4(2-14)1-13(10(18)12-8)9-7(17)6(16)5(3-15)19-9/h1,5-7,9,14-17H,2-3H2,(H2,11,12,18)/t5-,6?,7+,9-/m1/s1
• InChIKey: NFEXJLMYXXIWPI-AOXOCZDOSA-N
• SMILES: C1=C(C(=NC(=O)N1C2C(C(C(O2)CO)O)O)N)CO

5-(Hydroxymethyl)cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
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