For research use only. Not for therapeutic Use.
5-Iodotubercidin (Cat No.:I002815) is a highly potent inhibitor of adenosine kinase, displaying an IC50 value of 26 nM. In addition to adenosine kinase, it also inhibits nucleoside transporters, CK1 (casein kinase 1), insulin receptor tyrosine kinase, PKA (protein kinase A), CK2 (casein kinase 2), and PKC (protein kinase C). This broad spectrum of kinase inhibition makes 5-Iodotubercidin a valuable tool in research, as it can modulate multiple signaling pathways and cellular processes involved in various diseases and biological systems.
| Catalog Number | I002815 |
| CAS Number | 24386-93-4 |
| Synonyms | (2R,3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C11H13IN4O4 |
| Purity | ≥95% |
| Target | Adenosine Kinase |
| Solubility | DMSO: ≥ 49 mg/mL |
| Storage | Store at -20°C |
| IC50 | 26 nM |
| InChIKey | WHSIXKUPQCKWBY-IOSLPCCCSA-N |
| Reference | <p style=/line-height:25px/> <br>[1]. Massillon D, Stalmans W, van de Werve G, Bollen M. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 ( Pt 1):123-8. <br>[2]. Parkinson FE, Geiger JD. Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells. J Pharmacol Exp Ther. 1996 Jun;277(3):1397-401. <br>[3]. Ugarkar BG, DaRe JM, Kopcho JJ et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43(15):2883-93. <br>[4]. García-Villafranca J, Castro J. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000. <br>[5]. De Antoni A, Maffini S, Knapp S A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199(2):269-84. |
