5-LOX-IN-1

• CAT Number: I042881
• CAS Number: 55040-82-9
• Molecular Formula: C20H18N2O2S
• Molecular Weight: 350.43
• Purity: ≥95%
• Synonyms: (2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)-phenylmethanone
• InChI: InChI=1S/C20H18N2O2S/c23-18(16-9-5-2-6-10-16)19-17(15-7-3-1-4-8-15)21-20(25-19)22-11-13-24-14-12-22/h1-10H,11-14H2
• InChIKey: LHLMRDAASBJJEP-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC(=C(S2)C(=O)C3=CC=CC=C3)C4=CC=CC=C4

5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation[1].
5-LOX-IN-1 (0-10 μM) inhibits 5-LOX with an IC50 value of 2.3 μM[1].

Reference

[1]. Sinha S, et al. Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase. Eur J Med Chem. 2018 Oct 5;158:34-50.
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