5-LOX-IN-2

• CAT Number: I040951
• CAS Number: 179691-97-5
• Molecular Formula: C17H16O4
• Molecular Weight: 284.31
• Purity: ≥95%
• Synonyms: 2-phenylethyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
• InChI: InChI=1S/C17H16O4/c18-15-7-8-16(19)14(12-15)6-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-6+
• InChIKey: OQKRMXDGEFRBAJ-RMKNXTFCSA-N
• SMILES: C1=CC=C(C=C1)CCOC(=O)C=CC2=C(C=CC(=C2)O)O

5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1].
5-LOX-IN-2 (Compound 10b) (0-100 μM; 4 days) reduces the cell viability of renal cancer cells[1].
5-LOX-IN-2 (Compound 10b) (0-10 μM; 24 hours) increases in LC3B and p62 expression, blocks of the autophagic flux in RCC4 cells, and induces apoptosis by activation of the caspase-3 pathway leading to cell death[1].

Reference

[1]. Selka A, et.al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur J Med Chem. 2019 Oct 1;179:347-357.
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