5-(N-Ethyl-N-isopropyl) Amiloride

• CAT Number: R000102
• CAS Number: 1154-25-2
• Molecular Formula: C11H18ClN7O
• Molecular Weight: 299.76
• Purity: ≥95%
• Synonyms: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide; EIPA; Ethylisopropylamiloride; L 593754; MH 12-43
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4℃
• IUPAC Name: 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
• InChI: 1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
• InChIKey: QDERNBXNXJCIQK-UHFFFAOYSA-N
• SMILES: CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C

5-(N-Ethyl-N-isopropyl) Amiloride is a modified version of amiloride, a potassium-sparing diuretic. It acts by inhibiting sodium channels in the kidney, which reduces sodium reabsorption and prevents excessive potassium loss. This compound is primarily used in research to explore its effects on ion transport and fluid balance. It is also investigated for its potential to modulate various ion channels in different tissues, with potential applications in treating conditions like hypertension, edema, and certain cardiovascular diseases.