5-(N,N-dimethyl)-Amiloride (hydrochloride)

• CAT Number: I011802
• CAS Number: 2235-97-4
• Molecular Formula: C8H13Cl2N7O
• Molecular Weight: 294.14
• Purity: ≥95%
• Target: Na+/H+ Exchanger (NHE)
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride
• InChI: InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
• InChIKey: IIUPTHVVXMBJMQ-UHFFFAOYSA-N
• SMILES: CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl

5-(N,N-Dimethyl)-Amiloride (Hydrochloride)(CAT: I011802) is a potent inhibitor of sodium-hydrogen exchangers (NHEs), specifically targeting NHE1, and exhibits additional activity against Na⁺/Ca²⁺ exchangers. This compound is widely used in cardiovascular and cancer research, where it is employed to study ion transport, pH regulation, and cellular proliferation mechanisms. By disrupting NHE1 activity, it can induce intracellular acidification, making it valuable for exploring tumor microenvironment dynamics and pH-dependent processes in cancer cells. 5-(N,N-Dimethyl)-Amiloride (Hydrochloride) also aids in investigating the role of ion exchange in ischemia, cardiac hypertrophy, and other pathophysiological conditions, serving as a critical tool for both basic and translational research.