5-(N,N-HEXAMETHYLENE)-AMILORIDE

• CAT Number: M047889
• CAS Number: 1428-95-1
• Molecular Formula: C12H18ClN7O
• Molecular Weight: 311.78
• Purity: ≥95%
• Target: Anti-infection
• Storage: Desiccate at +4 ℃
• IUPAC Name: 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• InChI: InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
• InChIKey: RQQJJXVETXFINY-UHFFFAOYSA-N
• SMILES: C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N

5-(N,N-Hexamethylene)-Amiloride (HMA) is a derivative of amiloride, widely studied as a potent inhibitor of Na⁺/H⁺ exchangers (NHEs) and acid-sensing ion channels (ASICs). It is particularly effective in blocking NHE1, making it valuable in research on cancer, cardiovascular diseases, and cellular pH regulation. HMA also inhibits sodium/calcium exchange and has applications in studies of tumor metastasis, acidification, and cell proliferation. Its specificity and potency make it a critical tool for exploring ion transport mechanisms and therapeutic interventions targeting pH-dependent cellular processes.