5-O-Methylembelin

• CAT Number: I042069
• CAS Number: 56005-10-8
• Molecular Formula: C18H28O4
• Molecular Weight: 308.41
• Purity: ≥95%
• Synonyms: 2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione
• InChI: InChI=1S/C18H28O4/c1-3-4-5-6-7-8-9-10-11-12-14-17(20)15(19)13-16(22-2)18(14)21/h13,20H,3-12H2,1-2H3
• InChIKey: KHBJLRRAMCJZLZ-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)OC)O

5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
5-O-Methylembelin (compound 3; 20 μM; 24 h) downregulates PCSK9 (IC50 value of 4.9 μM), IDLR, and SREBP2 mRNA expression significantly[1].

Reference

[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.
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