5/'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3/'-O-(4,4/'-DIMETHOXYTRITYL)-THYMIDINE

• CAT Number: M114796
• CAS Number: 134031-86-0
• Molecular Formula: C40H49N4O9P
• Molecular Weight: 760.81
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile
• InChI: InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(47,50-23-11-22-41)51-26-36-35(24-37(52-36)43-25-29(5)38(45)42-39(43)46)53-40(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,54?/m0/s1
• InChIKey: BEMDXQXSHVUENL-JYQXRUAGSA-N
• SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(N(C(C)C)C(C)C)OCCC#N)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

5′-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)phosphinyl]-3′-O-(4,4′-Dimethoxytrityl)-Thymidine（Cat No.:M114796）is a synthetic nucleotide derivative commonly used in oligonucleotide synthesis. The compound features protective groups, such as the 4,4′-dimethoxytrityl (DMT) on the 3′-hydroxyl and a cyanoethoxyphosphinyl group, which aid in the stepwise assembly of DNA and RNA strands during solid-phase synthesis. Its structure allows for efficient coupling and deprotection cycles, making it essential in creating custom oligonucleotides for research in genomics, molecular diagnostics, and therapeutic applications, particularly in the development of antisense therapies and gene editing technologies.