For research use only. Not for therapeutic Use.
5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA analog. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation[1].
| Catalog Number | I045220 |
| CAS Number | 2990123-10-7 |
| Synonyms | acetyloxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate |
| Molecular Formula | C19H17NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17NO4/c1-13(21)23-12-24-19(22)10-16-11-20-18-8-7-15(9-17(16)18)14-5-3-2-4-6-14/h2-9,11,20H,10,12H2,1H3 |
| InChIKey | FGVMSTLYCNILJO-UHFFFAOYSA-N |
| SMILES | CC(=O)OCOC(=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3 |
| Reference | [1]. Negishi T, et al. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2022 Feb 4;220(2):iyab218. |
