(5-Phenyl-2-ureido)thiophene-3-carboxamide

• CAT Number: R006639
• CAS Number: 354811-10-2
• Molecular Formula: C12H11N3O2S
• Molecular Weight: 261.299
• Purity: ≥95%
• Synonyms: 2-[(Aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide
• Storage: -20°C
• IUPAC Name: 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
• InChI: InChI=1S/C12H11N3O2S/c13-10(16)8-6-9(7-4-2-1-3-5-7)18-11(8)15-12(14)17/h1-6H,(H2,13,16)(H3,14,15,17)
• InChIKey: PSVUSJKZJQMCSP-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC(=C(S2)NC(=O)N)C(=O)N

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.