For research use only. Not for therapeutic Use.
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC<sub>50</sub> = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.
| CAS Number | 354811-10-2 |
| Synonyms | 2-[(Aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide; |
| Molecular Formula | C12H11N3O2S |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide |
| InChI | InChI=1S/C12H11N3O2S/c13-10(16)8-6-9(7-4-2-1-3-5-7)18-11(8)15-12(14)17/h1-6H,(H2,13,16)(H3,14,15,17) |
| InChIKey | PSVUSJKZJQMCSP-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC(=C(S2)NC(=O)N)C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
