5(S),12(S)-DiHETE

• CAT Number: R067266
• CAS Number: 79056-01-2
• Molecular Formula: C11H14N4O4
• Molecular Weight: 266.26
• Purity: ≥95%
• Synonyms: 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
• Storage: -20°C
• IUPAC Name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
• InChI: InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
• InChIKey: IWKXDMQDITUYRK-KUBHLMPHSA-N
• SMILES: C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O

5(S),12(S)-DiHETE (5(S),12(S)-Dihydroxyeicosatetraenoic Acid)(CAT: R067266) is a bioactive lipid derived from arachidonic acid, a polyunsaturated fatty acid involved in the inflammatory response. It is produced through the sequential action of two lipoxygenase enzymes, 5-lipoxygenase and 12-lipoxygenase, which introduce hydroxyl groups at the 5th and 12th carbon positions of arachidonic acid. This compound plays a significant role in the regulation of inflammation and immune responses. 5(S),12(S)-DiHETE has been studied for its involvement in various biological processes, including the modulation of leukocyte function, the regulation of vascular tone, and the promotion of angiogenesis. It is also implicated in the pathophysiology of inflammatory diseases, such as asthma, atherosclerosis, and certain cancers, making it a target of interest in pharmacological research aimed at developing anti-inflammatory therapies.