5(S)-HEPE

• CAT Number: R067223
• CAS Number: 92008-51-0
• Molecular Formula: C20H30O3
• Molecular Weight: 318.5
• Purity: ≥95%
• Synonyms: 5S-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid
• Storage: -20°C
• InChI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h3-4,6-7,9-10,12-14,16,19,21H,2,5,8,11,15,17-18H2,1H3,(H,22,23)/b4-3-,7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
• InChIKey: FTAGQROYQYQRHF-GHWNLOBHSA-N
• SMILES: CC/C=CC/C=CC/C=CC/C=CC=C/[C@@H](O)CCCC(=O)O

5(S)-<wbr></wbr>HEPE is produced by 5-<wbr></wbr>lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA). While the synthesis of 5(S)-<wbr></wbr>HEPE from EPA by tissue homogenates has been demonstrated, the biological activity of 5(S)-<wbr></wbr>HEPE is poorly documented. It remains to be determined whether this activity differs substantially from that of 5(S)-<wbr></wbr>HETE (Catalog No. 34230).

Reference

1.Kulkarni, P.S.,Kaufman, P.L. and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. Journal of Ocular Pharmacology 3, 349-356 (1987).