For research use only. Not for therapeutic Use.
5-<wbr></wbr><em>trans</em> PGE<sub>2</sub> occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE<sub>1</sub>. It is 18 times more potent than PGE<sub>2</sub> in activating adenylate cyclase in NCB-<wbr></wbr>20 cell homogenates. 5-<wbr></wbr><em>trans</em> PGE<sub>2</sub> accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-<wbr></wbr>type plasminogen activator. It also inhibits platelet aggregation in human PRP with an IC<sub>50</sub> of 180 nM.
| Catalog Number | R064716 |
| CAS Number | 36150-00-2 |
| Synonyms | trans-Dinoprostone;5,6-trans PGE2 |
| Molecular Formula | C20H32O5 |
| Purity | ≥95% |
| Target | GPCR/G Protein |
| Storage | -20°C |
| IUPAC Name | (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid |
| InChI | InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,19+/m0/s1 |
| InChIKey | XEYBRNLFEZDVAW-BRNHSORCSA-N |
| SMILES | CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O |
| Reference | 1.Bundy, G.L.,Schneider, W.P.,Lincoln, F.H., et al. Isolation of a new naturally occurring prostaglandin, 5-trans-PGA2. Synthesis of 5-trans-PGE2 and 5-trans-PGF2α. Journal of the American Chemical Society 94, 2124 (1972). |
