5(Z),8(Z),11(Z)-Eicosatrienoic Acid

• CAT Number: R067710
• CAS Number: 20590-32-3
• Molecular Formula: C20H34O2
• Molecular Weight: 306.5
• Purity: ≥95%
• Synonyms: Mead Acid
• Target: Disease Research Fields
• Storage: -20°C
• InChI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h9-10,12-13,15-16H,2-8,11,14,17-19H2,1H3,(H,21,22)/b10-9-,13-12-,16-15-
• InChIKey: UNSRRHDPHVZAHH-YOILPLPUSA-N
• SMILES: CCCCCCCC/C=CC/C=CC/C=CCCCC(=O)O

Eicosatrienoic acid accumulates in the tissues of animals fed diets deficient in both ω-<wbr></wbr>3 and ω-<wbr></wbr>6 fatty acids. It can be converted to 3-<wbr></wbr>series cysteinyl-<wbr></wbr>leukotrienes but cannot serve as a COX substrate. The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs.

Reference

1.Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 20, 224-231 (1990).