5,5,5-Trifluoro-DL-leucine

• CAT Number: I043023
• CAS Number: 2792-72-5
• Molecular Formula: C6H10F3NO2
• Molecular Weight: 185.14
• Purity: ≥95%
• Synonyms: 2-amino-5,5,5-trifluoro-4-methylpentanoic acid
• InChI: InChI=1S/C6H10F3NO2/c1-3(6(7,8)9)2-4(10)5(11)12/h3-4H,2,10H2,1H3,(H,11,12)
• InChIKey: XFGVJLGVINCWDP-UHFFFAOYSA-N
• SMILES: CC(CC(C(=O)O)N)C(F)(F)F

5,5,5-Trifluoro-DL-leucine（Cat No.:I043023）is a fluorinated leucine analog used in biochemical research, medicinal chemistry, and protein engineering. The trifluoromethyl (-CF₃) group at the γ-carbon enhances hydrophobicity, metabolic stability, and enzyme resistance, making it valuable in fluorinated peptide design and metabolic studies. This compound is widely applied in drug discovery, structural biology, and enzyme inhibition research, where fluorination can alter protein folding, binding interactions, and bioactivity. It serves as a key tool in synthetic biology, metabolic labeling, and fluorinated pharmaceutical development, providing insights into amino acid transport and protein stability.