5,7-Dichlorokynurenic acid

• CAT Number: M111623
• CAS Number: 131123-76-7
• Molecular Formula: C10H5Cl2NO3
• Molecular Weight: 258.06
• Purity: ≥95%
• Synonyms: 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
• InChI: InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
• InChIKey: BGKFPRIGXAVYNX-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C2=C1NC(=CC2=O)C(=O)O)Cl)Cl

5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].

Reference

[1]. D McNamara, et al.  5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20.
 [Content Brief]