For research use only. Not for therapeutic Use.
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. <span class=/itemid/>34720</span>), a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.
| Catalog Number | R066577 |
| CAS Number | 339534-01-9 |
| Synonyms | HETE Analog 1 |
| Molecular Formula | C20H32O3 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h8-11,19,21H,2-7,12-13,15-16,18H2,1H3,(H,22,23)/b10-8-,11-9-/t19-/m1/s1 |
| InChIKey | FXVHFLDCTFMIGD-DPTNXLIISA-N |
| SMILES | CCCCC[C@@H](O)C#C/C=CCCCC/C=CCCCC(O)=O |
| Reference | 1.Pfister, S.L.,Klimko, P.G. and Conrow, R.E. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity. Prostaglandins & Other Lipid Mediators Apr, (2016). |
