(5Z,2E)-CU-3

• CAT Number: I018150
• CAS Number: 1815598-71-0
• Molecular Formula: C₁₆H₁₂N₂O₄S₃
• Molecular Weight: 392.47
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

Reference

[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.