For research use only. Not for therapeutic Use.
6-Alpha Naloxol (Cat No.: I002576) is a biologically active metabolite of naloxone, an opioid antagonist used to counteract opioid overdose. It exhibits partial opioid receptor activity, primarily interacting with the mu-opioid receptor. While it retains some antagonist properties, it has reduced potency compared to naloxone. Research suggests its potential role in modulating opioid effects and withdrawal symptoms. As a naloxone derivative, 6-alpha naloxol is of interest in pharmacological studies related to opioid receptor interactions, addiction treatment, and pain management strategies.
CAS Number | 20410-95-1 |
Synonyms | (5α,6α)-4,5- |
Molecular Formula | C19H23NO4 |
Purity | ≥95% |
Target | opioid antagonist |
Solubility | 10 mM in DMSO |
Storage | -20°C |
IUPAC Name | (4R,4aS,7S,7aR,12bS)-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol |
InChI | 1S/C19H23NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,13-14,17,21-23H,1,5-10H2/t13-,14+,17-,18-,19+/m0/s1 |
InChIKey | HMWHERQFMBEHNG-AQQQZIQISA-N |
SMILES | C=CCN1CC[C@]23[C@@H]4[C@H](CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)O |
Reference | <p style=/line-height:25px/> <br>[2]. Csaba Simon, et al. Stereoselective synthesis of β-naltrexol, β-naloxol β-naloxamine, β-naltrexamine and related compounds by the application of the mitsunobu reac. Tetrahedron <br>[3]. Schulteis G, et al. Relative potency of the opioid antagonists naloxone and 6-alpha-naloxol to precipitate withdrawal from acute morphine dependence varies with time post-antagonist. Pharmacol Biochem Behav. 2009 Mar;92(1):157-63. </p> |