6-Azauridine

• CAT Number: I012078
• CAS Number: 54-25-1
• Molecular Formula: C8H11N3O6
• Molecular Weight: 245.19
• Purity: ≥95%
• Synonyms: 2-β-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione, 6-Azauracil riboside
• Target: Nucleoside Antimetabolite/Analog
• Solubility: H₂O
• Storage: 2-8°C
• IUPAC Name: 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione
• InChI: InChI=1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1
• InChIKey: WYXSYVWAUAUWLD-SHUUEZRQSA-N
• SMILES: C1=NN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

6-Azauridine（Cat No.:I012078）is a pyrimidine analog and antimetabolite with antiviral and anticancer properties. It inhibits orotidylate decarboxylase, disrupting pyrimidine biosynthesis and impairing RNA and DNA synthesis in rapidly proliferating cells and viruses. 6-Azauridine has been studied for its efficacy against various RNA viruses and certain cancers, particularly leukemia. Its mechanism of action makes it a valuable tool in exploring metabolic pathways, nucleotide analog therapies, and antiviral drug development. Additionally, it provides insights into the regulation of nucleotide metabolism and its role in therapeutic strategies targeting proliferative diseases.