6-Azido-hexylamine

• CAT Number: I044634
• CAS Number: 349553-73-7
• Molecular Formula: C6H14N4
• Molecular Weight: 142.20
• Purity: ≥95%
• Synonyms: 6-azidohexan-1-amine
• InChI: InChI=1S/C6H14N4/c7-5-3-1-2-4-6-9-10-8/h1-7H2
• InChIKey: CLQMAUAPICAWGT-UHFFFAOYSA-N
• SMILES: C(CCCN=[N+]=[N-])CCN

6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 6-Azido-hexylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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