6-CEPN

• CAT Number: I020999
• CAS Number: 1054549-73-3
• Molecular Formula: C23H18O5
• Molecular Weight: 374.39
• Purity: ≥95%
• Synonyms: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(E)-2-phenylethenyl]-2,3-dihydrochromen-4-one
• InChI: InChI=1S/C23H18O5/c24-16-9-7-15(8-10-16)20-13-19(26)22-21(28-20)12-18(25)17(23(22)27)11-6-14-4-2-1-3-5-14/h1-12,20,24-25,27H,13H2/b11-6+
• InChIKey: WBONVHMXTSZBAF-IZZDOVSWSA-N
• SMILES: C1C(OC2=C(C1=O)C(=C(C(=C2)O)C=CC3=CC=CC=C3)O)C4=CC=C(C=C4)O

6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase)[1].
6-CEPN (10-100 μM, 24 h) decreases cell activity in a dose-dependent manner in SW620, SW480, HCT116 and HT29 cells,and a can resist cell proliferation[1].
6-CEPN (10 μM, 24 h) can block the cell cycle in G1 phase in SW620 and HCT116 cells[1].
6-CEPN (10 μM, 24 h) induces cell necrosis in SW620 and HCT116 cells [1].
6-CEPN (2.5-10 μM, 24 h) induces autophagy and cell death of colon cancer cells by inhibiting RAS activation in SW620 and HCT116 cancer cells[1].

Reference

[1]. Zhao Y, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR), 2016, 68(Null).
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