6-Hydroxy Melatonin

• CAT Number: R002856
• CAS Number: 2208-41-5
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.282
• Purity: ≥95%
• Synonyms: N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide; 6-Hydroxy-N-acetyl-5-methoxytryptamine
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
• InChI: InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
• InChIKey: OMYMRCXOJJZYKE-UHFFFAOYSA-N
• SMILES: CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)O

6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [ Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes. Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.