(6-L-Leucine)-Leuprolide

• CAT Number: R061782
• CAS Number: 54785-87-4
• Molecular Formula: C59H84N16O12
• Molecular Weight: 1209.421
• Purity: ≥95%
• Synonyms: 6-L-leucine-9-(N-ethyl-L-prolinamide)-1-9-Luteinizing hormone-releasing factor;?6-L-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-Luteinizing hormone-releasing factor
• Storage: -20°C
• IUPAC Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• InChI: InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
• InChIKey: GFIJNRVAKGFPGQ-UILVTTEASA-N
• SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6

(6-L-Leucine)-Leuprolide is a potent synthetic peptide and analog of leuprolide, an established gonadotropin-releasing hormone (GnRH) agonist. This compound features a leucine residue at the sixth position, enhancing its stability and bioactivity. It is primarily used in the treatment of hormone-sensitive conditions, such as prostate cancer and endometriosis, by regulating hormone levels. The modification aims to improve its pharmacokinetic properties and efficacy. Ongoing research is focused on optimizing its therapeutic applications and understanding its mechanisms of action in various medical contexts.