6-Maleimidocaproic acid-PFP ester

• CAT Number: I015711
• CAS Number: 692739-25-6
• Molecular Formula: C₁₆H₁₂F₅NO₄
• Molecular Weight: 377.26
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2,3,4,5,6-pentafluorophenyl) 6-(2,5-dioxopyrrol-1-yl)hexanoate
• InChI: InChI=1S/C16H12F5NO4/c17-11-12(18)14(20)16(15(21)13(11)19)26-10(25)4-2-1-3-7-22-8(23)5-6-9(22)24/h5-6H,1-4,7H2
• InChIKey: CIQYBTAUACRWKP-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCCCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F

6-Maleimidocaproic acid-PFP ester（Cat No.:I015711） is a bifunctional linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). The linker consists of a maleimide moiety that reacts with cysteine residues of the target protein and a PFP ester that reacts with amino groups of the ligand. The alkyl chain in the linker provides the necessary flexibility for the ligand to bind to the target protein. 6-Maleimidocaproic acid-PFP ester has been used successfully in the development of PROTACs targeting a wide range of proteins implicated in cancer and other diseases.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562