6-Methylflavone

For research use only. Not for therapeutic Use.

  • CAT Number: I020410
  • CAS Number: 29976-75-8
  • Molecular Formula: C16H12O2
  • Molecular Weight: 236.27
  • Purity: ≥95%
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6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].


Catalog Number I020410
CAS Number 29976-75-8
Synonyms

6-methyl-2-phenylchromen-4-one

Molecular Formula C16H12O2
Purity ≥95%
InChI InChI=1S/C16H12O2/c1-11-7-8-15-13(9-11)14(17)10-16(18-15)12-5-3-2-4-6-12/h2-10H,1H3
InChIKey NOQJBXPAMJLUSS-UHFFFAOYSA-N
SMILES CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3
Reference

[1]. Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.
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