6-OAU

• CAT Number: I005018
• CAS Number: 83797-69-7
• Molecular Formula: C12H21N3O2
• Molecular Weight: 239.319
• Purity: ≥95%
• Synonyms: 6-(octylamino)-2,4(1H,3H)-pyrimidinedione
• Target: Stem Cell/Wnt
• Solubility: DMSO : ＜ 7 mg/mL
• Storage: Store at -20°C
• IC50: 105 nM [1]
• IUPAC Name: 6-(octylamino)-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17)
• InChIKey: PFSWASUQURIOOR-UHFFFAOYSA-N
• SMILES: CCCCCCCCNC1=CC(=O)NC(=O)N1

6-OAU (GTPL5846; 6-n-octylaminouracil)(CAT: I005018) serves as a surrogate agonist for GPR84, effectively activating human GPR84 when coupled with Gqi5 chimera in HEK293 cells. Its potency is evident with an EC50 of 105 nM as determined through the PI assay. This compound’s ability to modulate GPR84 highlights its potential importance in studying G protein-coupled receptor signaling pathways and may offer insights into the physiological and pathological roles influenced by GPR84 activation.

Reference

[1]. Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91.