6,7-Dihydroxycoumarin (Esculetin)

For research use only. Not for therapeutic Use.

  • CAT Number: R024829
  • CAS Number: 305-01-1
  • Molecular Formula: C9H6O4
  • Molecular Weight: 178.143
  • Purity: ≥95%
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Esculetin is a natural plant phenolic that shares features of coumarins and catechols. It inhibits lipoxygenases (LOs), including 5-LO and 12-LO (ID<sub>50</sub>s = 4 and 2.5 µM, respectively). This action is likely due to its ability to bind iron, as it also inhibits other iron-containing enzymes, including the lysine-specific demethylase KDM5B. Like other coumarins, esculetin promotes TRAIL-induced apoptosis in cancer cells. Esculetin is also used as an antioxidant to reduce reactive oxygen species and modulate oxidant-sensitive enzymes. Esculetin, which can be derived from esculin by β-glucosidases, also has anti-fungal activities.


CAS Number 305-01-1
Synonyms

Esculetin; 6,7-Dihydroxy-2-benzopyrone; 6,7-Dihydroxycoumarin; Aesculetin; Asculetine; Cichorigenin; Cichoriin Aglycon; Esculetol; Esculin Aglycon; NSC 26428

Molecular Formula C9H6O4
Purity ≥95%
Target PI3K
Storage Room temperature
IUPAC Name 6,7-dihydroxychromen-2-one
InChI InChI=1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChIKey ILEDWLMCKZNDJK-UHFFFAOYSA-N
SMILES C1=CC(=O)OC2=CC(=C(C=C21)O)O

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