6a,​9a-​Difluoro-11b,21-dihydroxy-pregna-1,4,16-triene-3,20-dione

• CAT Number: C000780
• CAS Number: 1270039-29-6
• Molecular Formula: C₂₁H₂₄F₂O₄
• Molecular Weight: 378.41
• Purity: ≥95%
• Synonyms: (6α,11β)-6,9-Difluoro-11,21-dihydroxy-pregna-1,4,16-triene-3,20-dione; (6α,11β)-6,9-Difluoro-11,21-dihydroxypregna-1,4,16-triene-3,20-dione
• Solubility: Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C, Inert atmosphere
• IUPAC Name: (6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C21H24F2O4/c1-19-9-18(27)21(23)14(12(19)3-4-13(19)17(26)10-24)8-16(22)15-7-11(25)5-6-20(15,21)2/h4-7,12,14,16,18,24,27H,3,8-10H2,1-2H3/t12-,14-,16-,18-,19-,20-,21-/m0/s1
• InChIKey: KVEOPUITANBHFN-FXZCQDAKSA-N
• SMILES: CC12CC(C3(C(C1CC=C2C(=O)CO)CC(C4=CC(=O)C=CC43C)F)F)O

6α,9α-Difluoro-11β,21-dihydroxy-pregna-1,4,16-triene-3,20-dione (Cat No.:C000780) is a synthetic corticosteroid compound with a modified pregnane structure. It features fluorine substitutions at positions 6 and 9, hydroxyl groups at positions 11 and 21, and a double bond at position 1. This compound is of interest in pharmaceutical research, potentially possessing anti-inflammatory or immunosuppressive properties. Researchers may investigate its effects on glucocorticoid receptors, its pharmacological profile, and potential therapeutic applications. Understanding its interactions with biological systems and its impact on various physiological processes could contribute to the development of targeted therapies for inflammatory conditions and autoimmune disorders.

Reference

Kapp, A., et al.: J. Allergy and Clin. Immunol., 110, 277 (2002); Yasueda, S., et al.: J. Pharm. Biomed. Anal., 30, 1735 (2003); Yamaguchi, M., et al.: Int. J. Pharm., 301, 121 (2005)