(6R)-FR054

• CAT Number: I015535
• CAS Number: 10378-06-0
• Molecular Formula: C₁₄H₁₉NO₈
• Molecular Weight: 329.30
• Purity: ≥95%
• Target: Apoptosis
• Storage: 4°C
• IUPAC Name: [(3aR,5R,6R,7R,7aR)-6,7-diacetyloxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazol-5-yl]methyl acetate
• InChI: InChI=1S/C14H19NO8/c1-6-15-11-13(22-9(4)18)12(21-8(3)17)10(5-19-7(2)16)23-14(11)20-6/h10-14H,5H2,1-4H3/t10-,11-,12+,13-,14+/m1/s1
• InChIKey: WZFQZRLQMXZMJA-RGDJUOJXSA-N
• SMILES: CC1=NC2C(C(C(OC2O1)COC(=O)C)OC(=O)C)OC(=O)C

(6R)-FR054 (Cat No.:I015535) is a selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the de novo synthesis of pyrimidines. By inhibiting DHODH, (6R)-FR054 disrupts cellular proliferation and has shown potential as a therapeutic agent in cancer and autoimmune diseases. It is of particular interest for its ability to target rapidly dividing cells, such as those found in tumors, without significantly affecting normal cells. Ongoing research is focused on optimizing its clinical applications.

Reference

[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.