(6R)-FR054

• CAT Number: I015535
• CAS Number: 10378-06-0
• Molecular Formula: C₁₄H₁₉NO₈
• Molecular Weight: 329.3
• Purity: ≥95%
• Target: Apoptosis
• Storage: 4°C
• IUPAC Name: [(3aR,5R,6R,7R,7aR)-6,7-diacetyloxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazol-5-yl]methyl acetate
• InChI: InChI=1S/C14H19NO8/c1-6-15-11-13(22-9(4)18)12(21-8(3)17)10(5-19-7(2)16)23-14(11)20-6/h10-14H,5H2,1-4H3/t10-,11-,12+,13-,14+/m1/s1
• InChIKey: WZFQZRLQMXZMJA-RGDJUOJXSA-N
• SMILES: CC1=NC2C(C(C(OC2O1)COC(=O)C)OC(=O)C)OC(=O)C

(6R)-FR054 (Cat No.:I015535) is an active isomer of FR054. FR054 is an inhibitor of the HBPase PGM3 with significant anti-breast cancer activity. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptosis.

Reference

[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.