For research use only. Not for therapeutic Use.
(6R)-ML753286（Cat No.:I041431）is a selective small-molecule inhibitor of the enzyme diacylglycerol kinase (DGK), specifically targeting the DGKα isoform. DGK enzymes regulate the levels of diacylglycerol (DAG), which plays a critical role in various cellular processes, including immune cell signaling and inflammation. By inhibiting DGKα, (6R)-ML753286 modulates DAG-mediated pathways, potentially reducing inflammatory responses and providing therapeutic benefits in conditions like autoimmune diseases, cancer, and cardiovascular disorders. Ongoing research is focused on evaluating the compound’s efficacy, safety, and its potential to target DGK-related pathways in disease treatment.
| Synonyms | (2R,5S,8R)-14-methoxy-5-methyl-2-(2-methylpropyl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| Molecular Formula | C20H25N3O3 |
| Purity | ≥95% |
| IUPAC Name | (2R,5S,8R)-14-methoxy-5-methyl-2-(2-methylpropyl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| InChI | InChI=1S/C20H25N3O3/c1-10(2)7-16-18-14(13-6-5-12(26-4)8-15(13)22-18)9-17-19(24)21-11(3)20(25)23(16)17/h5-6,8,10-11,16-17,22H,7,9H2,1-4H3,(H,21,24)/t11-,16+,17+/m0/s1 |
| InChIKey | XDVXQQDQFWVCAU-YMRXKLBXSA-N |
| SMILES | C[C@H]1C(=O)N2[C@H](CC3=C([C@H]2CC(C)C)NC4=C3C=CC(=C4)OC)C(=O)N1 |
