For research use only. Not for therapeutic Use.
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.
| Catalog Number | R045934 |
| CAS Number | 603-00-9 |
| Synonyms | 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-Hydroxypropyl)theophylline; (+/-)-Proxyphyllin; 1,3-Dimethyl-7-(2-hydroxypropyl)?xanthine; Brontyl; Hydroxypropyltheophylline; Monophylline; NSC 163343; Oxypropyltheophylline; Pro |
| Molecular Formula | C10H14N4O3 |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| InChIKey | KYHQZNGJUGFTGR-UHFFFAOYSA-N |
| Reference | </br>1:Antianaphylactic and antiasthmatic properties of new piperazinyl 7-(beta-hydroxypropyl)-theophylline derivatives in guinea pigs. Czarnecki R, Librowski T, Pawłowski M.Pol J Pharmacol. 2001 Mar-Apr;53(2):131-6. PMID: 11787952 Free Article</br>2:[Hypolipemic and antiatherogenic effects of 2/’,4/’ dichlorobenzoate of 7-gamma(beta-hydroxypropyl)-theophylline (HME2)]. Wójcicki J, Samochowiec L, Bartłomowicz B, Kadłubowska D, Marona H.Acta Pol Pharm. 1988;45(4):362-8. Polish. No abstract available. PMID: 3245473 </br>3:Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Selvig K, Bjerve KS.Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2. PMID: 6291318 </br>4:[The polymorphism of 7-(beta-hydroxypropyl)- and 7-(beta, gamma-dihydroxypropyl) theophylline]. Eckert T, Müller J.Arch Pharm (Weinheim). 1977 Jan;310(1):70-5. German. No abstract available. PMID: 843200 </br>5:Gas chromatographic determination of 7-(beta-hydroxypropyl) theophylline in biological fluids. Ervik M.Acta Pharm Suec. 1970 Dec;7(6):697-700. No abstract available. PMID: 5511719 </br>6:[Colorimetric assay of 7-(beta-hydroxypropyl)-theophylline and other purines]. Marini Scotti M.Boll Chim Farm. 1965 Jun;104(6):356-61. Italian. No abstract available. PMID: 5841210 |
