7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

For research use only. Not for therapeutic Use.

  • CAT Number: R011582
  • CAS Number: 1159977-58-8
  • Molecular Formula: C42H44N2O6S
  • Molecular Weight: 704.87
  • Purity: ≥95%
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7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM[1].
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is binding to the domain (LBD) of LRH-1[1].


Catalog Number R011582
CAS Number 1159977-58-8
Synonyms

[6-hydroxy-2-(4-hydroxyphenyl)-7-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

Molecular Formula C42H44N2O6S
Purity ≥95%
InChI InChI=1S/C42H44N2O6S/c45-32-13-7-31(8-14-32)41-37(39(47)29-9-15-33(16-10-29)49-27-25-43-21-3-1-4-22-43)35-19-20-36(46)38(42(35)51-41)40(48)30-11-17-34(18-12-30)50-28-26-44-23-5-2-6-24-44/h7-20,45-46H,1-6,21-28H2
InChIKey ZIQUILNLPRCFRB-UHFFFAOYSA-N
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4C(=O)C5=CC=C(C=C5)OCCN6CCCCC6)O)C7=CC=C(C=C7)O
Reference

[1]. Rey, J., et al. Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation. ChemMedChem,2012; 7(11), 1909–1914.

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