7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA

• CAT Number: I040333
• Molecular Formula: C24H21F4N3O6
• Molecular Weight: 523.43
• Purity: ≥95%
• Synonyms: (19S)-10-(aminomethyl)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C22H20FN3O4.C2HF3O2/c1-3-22(29)15-5-18-19-13(8-26(18)20(27)14(15)9-30-21(22)28)12(7-24)11-4-10(2)16(23)6-17(11)25-19;3-2(4,5)1(6)7/h4-6,29H,3,7-9,24H2,1-2H3;(H,6,7)/t22-;/m0./s1
• InChIKey: OWUWBPSWDMGYAL-FTBISJDPSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=C(C(=C5)C)F)N=C4C3=C2)CN)O.C(=O)(C(F)(F)F)O

7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA can be used for the synthesis of camptothecin antibody-drug conjugate (ADC)[1].

Reference

[1]. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392.
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