7-BIA

• CAT Number: I019197
• CAS Number: 1313403-49-4
• Molecular Formula: C15H18O6
• Molecular Weight: 294.30
• Purity: ≥95%
• Synonyms: 7-butoxy-3-hydroxy-6-methoxy-1-oxo-3,4-dihydroisochromene-5-carbaldehyde
• InChI: InChI=1S/C15H18O6/c1-3-4-5-20-12-6-10-9(7-13(17)21-15(10)18)11(8-16)14(12)19-2/h6,8,13,17H,3-5,7H2,1-2H3
• InChIKey: DAVCIYWSVYDJKW-UHFFFAOYSA-N
• SMILES: CCCCOC1=C(C(=C2CC(OC(=O)C2=C1)O)C=O)OC

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].
7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1].
7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1].

Reference

[1]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602.
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