7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt; 7-deaza-dATP, ZTP.

• CAT Number: M003277
• CAS Number: 101515-08-6
• Molecular Formula: C11H16LiN4O13P3
• Molecular Weight: 512.13
• Purity: ≥95%
• Synonyms: 7-Deaza-2′-deoxyguanosine triphosphate； 7-deaza-2′-deoxy-guanosine-5′-triphosphate.
• Target: Telomerase
• Storage: -20°C
• IUPAC Name: [[(2R,3S,5R)-5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• InChI: 1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)/t6-,7+,8+/m0/s1
• InChIKey: DLLXAZJTLIUPAI-XLPZGREQSA-N
• SMILES: P(O)(O)(=O)O[P@@](=O)(O[P@@](=O)(OC[C@@H]1[C@H](C[C@@H](n2ccc3c(=O)nc(N)[nH]c23)O1)O)O)O

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt (7-deaza-dGTP), also known as ZTP, is a modified nucleotide analog where the nitrogen at position 7 of the purine ring in guanosine is replaced with a carbon atom. This modification alters the chemical properties of the nucleotide, making it useful in molecular biology applications, particularly in polymerase chain reactions (PCR) and DNA sequencing. 7-Deaza-dGTP is used to reduce secondary structure formation in GC-rich regions of DNA, improving the efficiency and accuracy of amplification and sequencing processes. The lithium salt form enhances its solubility and stability, making it more convenient for biochemical and enzymatic reactions.