7-Deaza-2',3'-dideoxyguanosine

• CAT Number: I044610
• CAS Number: 111869-49-9
• Molecular Formula: C11H14N4O3
• Molecular Weight: 250.25
• Purity: ≥95%
• Synonyms: 2-amino-7-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one
• InChI: InChI=1S/C11H14N4O3/c12-11-13-9-7(10(17)14-11)3-4-15(9)8-2-1-6(5-16)18-8/h3-4,6,8,16H,1-2,5H2,(H3,12,13,14,17)/t6-,8+/m0/s1
• InChIKey: IRKZBFORRGBSAO-POYBYMJQSA-N
• SMILES: C1CC(OC1CO)N2C=CC3=C2N=C(NC3=O)N

7-Deaza-2′,3′-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].

Reference

[1]. Nicholas A Boyle, et al. Synthesis of 2′,3′-dideoxynucleoside 5′-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48(7):2695-700.
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