For research use only. Not for therapeutic Use.
7-Deazaadenosine-5′-O-triphosphate (7-CH-ATP), sodium salt（Cat No.:M120093） is a modified form of adenosine triphosphate (ATP) with a 7-data substitution on the adenine ring. This modification replaces the nitrogen at the 7th position of adenine with carbon, resulting in a reduced ability to form hydrogen bonds. 7-CH-ATP is used as a substrate in enzymatic assays and as a tool in nucleotide biochemistry and molecular biology research. Its unique structure alters the binding properties and interactions with enzymes and proteins, making it valuable for studying nucleic acid metabolism, DNA replication, and other cellular processes.
| Catalog Number | M120093 |
| CAS Number | 10058-66-9 |
| Synonyms | 7- Deazaadenosine- 5′- O- triphosphate ( 7-CH-ATP ), sodium salt |
| Molecular Formula | C₁₁H₁₇N₄O₁₃P₃ (free acid) |
| Purity | 95% |
| Appearance | 10 mM aqueous solution of pH 7.6 |
| Storage | -20°C |
| Analysis method | HPLC |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| InChI | InChI=1S/C11H17N4O13P3/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(17)7(16)6(26-11)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,4,6-8,11,16-17H,3H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t6-,7-,8-,11-/m1/s1 |
| InChIKey | GVVRDIINMFAFEO-KCGFPETGSA-N |
| SMILES | C1=CN(C2=NC=NC(=C21)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O |
| Reference | 1. Wieczorek A., Dinter-Gottlieb G.Gottlieb P. A., Bioorg. Med. Chem., 4, 987 – 994 (1994), "Evidence that Total Subsitution of Adenine with 7-Deaza-adenine in the HDV Antigenomic Ribozyme Changes the Kinetics of RNA Folding"<br /> |
