7-Ethoxy-4-methylcoumarin

• CAT Number: R066587
• CAS Number: 87-05-8
• Molecular Formula: C12H12O3
• Molecular Weight: 204.22
• Purity: ≥95%
• Synonyms: 7-ethoxy-4-methylchromen-2-one
• InChI: InChI=1S/C12H12O3/c1-3-14-9-4-5-10-8(2)6-12(13)15-11(10)7-9/h4-7H,3H2,1-2H3
• InChIKey: NKRISXMDKXBVRJ-UHFFFAOYSA-N
• SMILES: CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C

7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2].

Reference

[1]. Kuhn UD, et al. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Exp Toxicol Pathol. 1998 Sep;50(4-6):491-6.
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[2]. Liu J, et al. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. 2016 Apr 5;55(13):1997-2007.
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