For research use only. Not for therapeutic Use.
7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling[1].
7-Fluorotryptamine (100 μM) hydrochloride induces β-arrestin recruitment by GPRC5A in the PRESTO-Tango assay[1].
7-Fluorotryptamine (50 μM, 8 h) hydrochloride together with TNFα down-regulates some TNFα-induced genes (eg: IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells[1].
7-Fluorotryptamine (0-100 μM, 16 h) hydrochloride exhibits no toxicity for mammalian cells (HTLA, HT-29 cell)[1].
| Catalog Number | M043285 |
| CAS Number | 159730-09-3 |
| Synonyms | 2-(7-fluoro-1H-indol-3-yl)ethanamine;hydrochloride |
| Molecular Formula | C10H12ClFN2 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H11FN2.ClH/c11-9-3-1-2-8-7(4-5-12)6-13-10(8)9;/h1-3,6,13H,4-5,12H2;1H |
| InChIKey | JWAZOMQARDNFMN-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C(=C1)F)NC=C2CCN.Cl |
| Reference | [1]. Zhao X, et al. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A. Nat Chem Biol. 2023 May 29. |
