7-Hydroxy-N-des{[2-(2-hydroxy)ethoxy]ethyl} Quetiapine Dihydrochloride

• CAT Number: C000683
• CAS Number: 1397181-83-7
• Molecular Formula: C₁₇H₁₇N₃OS. 2HCl
• Molecular Weight: 384.32
• Purity: ≥95%
• Synonyms: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepin-7-ol Dihydrochloride; M 236303
• Solubility: Methanol (Slightly), Water (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C, Hygroscopic
• IUPAC Name: 6-piperazin-1-ylbenzo[b][1,4]benzothiazepin-2-ol;dihydrochloride
• InChI: InChI=1S/C17H17N3OS.2ClH/c21-12-5-6-14-16(11-12)22-15-4-2-1-3-13(15)17(19-14)20-9-7-18-8-10-20;;/h1-6,11,18,21H,7-10H2;2*1H
• InChIKey: YJPLRCWLXWOWSA-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=NC3=C(C=C(C=C3)O)SC4=CC=CC=C42.Cl.Cl

7-Hydroxy-N-des{[2-(2-hydroxy)ethoxy]ethyl} Quetiapine Dihydrochloride (Cat No.:C000683) is a derivative of quetiapine, an antipsychotic medication used to treat schizophrenia and bipolar disorder. The compound features a modification involving a hydroxy ethoxy ethyl group attached to the N-dialkyl metabolite of quetiapine, specifically at the 7-hydroxy position. This modification may influence the compound’s pharmacological properties, metabolism, or interactions with neurotransmitter receptors.

Reference

McConville, B., et al.: J. Clin. Psychiatry, 61, 252