7-Hydroxy Warfarin

• CAT Number: R005456
• CAS Number: 17834-03-6
• Molecular Formula: C19H16O5
• Molecular Weight: 324.332
• Purity: ≥95%
• Synonyms: 4,7-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 3-(α-Acetonylbenzyl)-4,7-dihydroxycoumarin
• Storage: -20°C
• IUPAC Name: 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
• InChI: InChI=1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3
• InChIKey: SKFYEJMLNMTTJA-UHFFFAOYSA-N
• SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=C(C=C(C=C3)O)OC2=O)O

7-hydroxy Warfarin is a metabolite of (-)-warfarin (Item No. 13531), which is a more potent vitamin K antagonist than (+)-warfarin (Item No. 13526). Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9). Stereoselective metabolism also occurs, and CYP2C9 is the primary enzyme responsible for metabolism of (-)-warfarin to 7-hydroxy warfarin.