7-Ketocholesterol

• CAT Number: R009252
• CAS Number: 566-28-9
• Molecular Formula: C27H44O2
• Molecular Weight: 400.64
• Purity: ≥95%
• Synonyms: (3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1
• InChIKey: YIKKMWSQVKJCOP-ABXCMAEBSA-N
• SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C(=O)C=C4[C@@]3(CC[C@@H](C4)O)C)C

7-Ketocholesterol（Cat No.:R009252）is an oxidized derivative of cholesterol, formed through enzymatic or non-enzymatic processes. It is a bioactive molecule involved in various pathological conditions, particularly in cardiovascular diseases and neurodegenerative disorders like Alzheimer’s. 7-Ketocholesterol contributes to endothelial dysfunction, promotes inflammation, and can damage cellular membranes, accelerating atherosclerosis and plaque formation. Additionally, its accumulation in the brain is linked to oxidative stress and neuronal degeneration. Due to its detrimental effects, 7-Ketocholesterol is a focus of research aimed at understanding its role in disease progression and developing therapeutic strategies to mitigate its impact.