7-methyl-6-Thioguanosine (technical grade)

• CAT Number: R065246
• CAS Number: 55727-10-1
• Molecular Formula: C11H15N5O4S
• Molecular Weight: 313.34
• Purity: ≥95%
• Synonyms: MESG
• Storage: -20°C
• IUPAC Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methylpurin-9-ium-6-thiolate
• InChI: InChI=1S/C11H15N5O4S/c1-15-3-16(8-5(15)9(21)14-11(12)13-8)10-7(19)6(18)4(2-17)20-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,21)/t4-,6-,7-,10-/m1/s1
• InChIKey: RFHIWBUKNJIBSE-KQYNXXCUSA-N
• SMILES: O[C@H]1[C@@H](O)[C@H](N2C=[N+](C)C3=C2N=C([NH-])NC3=S)O[C@@H]1CO

7-Methyl-6-Thioguanosine(CAT: R065246) is a modified nucleoside that features a methyl group at the 7th position and a sulfur atom replacing the oxygen at the 6th position of guanosine. This compound is significant in the study of nucleic acid chemistry, particularly in understanding RNA and DNA modifications and their effects on genetic expression and stability. 7-Methyl-6-Thioguanosine is commonly used in research investigating the mechanisms of action of antimetabolites, the effects of methylation and thiolation on nucleic acid function, and the development of potential chemotherapeutic agents targeting nucleic acids.

Reference

1.Webb, M.R. A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems. Proceedings of the National Academy of Sciences of the United States of America 89(11), 4884-4887 (1992).