7-Methylguanine

• CAT Number: R058540
• CAS Number: 578-76-7
• Molecular Formula: C6H7N5O
• Molecular Weight: 165.156
• Purity: ≥95%
• Synonyms: 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one; 2-Amino-7-methylhypoxanthine; N7-Methylguanine; NSC 193444; NSC 19647
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: 2-amino-7-methyl-3H-purin-6-one
• InChI: InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
• InChIKey: FZWGECJQACGGTI-UHFFFAOYSA-N
• SMILES: CN1C=NC2=C1C(=O)N=C(N2)N

7-Methylguanine is a metabolite of the natural purine base whose N9 position is available for chemical modifications. This genotoxic adduct can be generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods. It is also considered to be a carcinogenic biomarker for cigarette smoking that is detectable in urine.