7-Methylguanosine 5'-diphosphate sodium

• CAT Number: M008741
• CAS Number: 104809-16-7
• Molecular Formula: C11H16N5NaO11P2
• Molecular Weight: 479.21
• Purity: ≥95%
• Synonyms: sodium;[[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] hydrogen phosphate
• InChI: InChI=1S/C11H17N5O11P2.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
• InChIKey: GWXMULHRNCYTBF-MCDZGGTQSA-M
• SMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)[O-])O)O.[Na+]

7-Methylguanosine 5′-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1].
7-Methylguanosine 5′-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1].
T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5′-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2].

Reference

[1]. Sonenberg N, et al. Nonspecific effect of m7GMP on protein-RNA interactions. J Biol Chem. 1978;253(19):6630-6632.
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[2]. Ignatochkina AV, et al. The messenger RNA decapping and recapping pathway in Trypanosoma. Proc Natl Acad Sci U S A. 2015;112(22):6967-6972.
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